Sodium-glucose cotransporter-2 inhibitors in combination with other glucose-lowering agents for the treatment of type 2 diabetes mellitus
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چکیده
منابع مشابه
Sodium-glucose cotransporter 2 inhibition in type 1 diabetes: simultaneous glucose lowering and renal protection?
Diabetic nephropathy is the most common cause of end-stage renal disease requiring chronic dialysis or renal transplantation, resulting in high morbidity, mortality and societal costs to Canadians. Unfortunately, glycemic targets are often not achieved, and existing medications that block the renin-angiotensin-aldosterone system only offer partial protection against the development of renal and...
متن کاملRole of sodium glucose cotransporter-2 inhibitors in type I diabetes mellitus
The burden of diabetes mellitus (DM) in general has been extensively increasing over the past few years. Selective sodium glucose cotransporter-2 (SGLT2) inhibitors were extensively studied in type 2 DM and found to have sustained urinary glucose loss, improvement of glycemic control, in addition to their proven metabolic effects on weight, blood pressure, and cardiovascular benefits. Type 1 DM...
متن کاملImpact of Sodium‐Glucose Cotransporter 2 Inhibitors on Nonglycemic Outcomes in Patients with Type 2 Diabetes
The efficacy of the sodium-glucose cotransporter 2 (SGLT2) inhibitors canagliflozin, dapagliflozin, and empagliflozin in reducing hyperglycemia in patients with type 2 diabetes is well documented. In addition, positive effects have been observed with these agents on nonglycemic variables, such as reductions in body weight and blood pressure, which may confer additional health benefits. SGLT2 in...
متن کاملRenal Sodium - Glucose Cotransporter Inhibition in the Management of Type 2 Diabetes 2 Mellitus 3
Revised 8-19-2015 (LOA) 1 Renal Sodium-Glucose Cotransporter Inhibition in the Management of Type 2 Diabetes 2 Mellitus 3 Muhammad A Abdul-Ghani, MD, PhD, Luke Norton, Ph.D., and Ralph A DeFronzo, MD 4 Division of Diabetes, University of Texas Health Science Center at San Antonio, Texas, USA 5 6
متن کاملClinical potential of sodium-glucose cotransporter 2 inhibitors in the management of type 2 diabetes
BACKGROUND The kidney plays an important role in glucose metabolism, and has been considered a target for therapeutic intervention. The sodium-glucose cotransporter type 2 (SGLT2) mediates most of the glucose reabsorption from the proximal renal tubule. Inhibition of SGLT2 leads to glucosuria and provides a unique mechanism to lower elevated blood glucose levels in diabetes. The purpose of this...
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ژورنال
عنوان ژورنال: Indian Journal of Endocrinology and Metabolism
سال: 2018
ISSN: 2230-8210
DOI: 10.4103/ijem.ijem_162_17